Paloxi

PALOXI® stroke DESCRIPTION ® Paloxi (palonosetron hydrochloride) is an antiemetic and anti maladynt agent. It is a serotonin subtype 3 (5-HT3) sensory sense organ thwarter with a concentrated blanket semblance for this receptor. Chemically, palonosetron hydrochloride is: (3aS)-2-[(S)-1-Azabicyclo [2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1oxo-1Hbenz[de]isoquinoline hydrochloride. The empirical polity is C19H24N2O.HCl, with a molecular weight of 332.87. Palonosetron hydrochloride exists as a single isomer and has the sp be-time activity geomorphologic formula: Palonosetron hydrochloride is a white to off -white gauzy powder. It is freely soluble in water, soluble in propylene glycol, and meagerly soluble in ethanol and 2 -propanol. ® Paloxi injection is a sterile, clear, colorless, non-pyrogenic, isotonic, buffered solution for intravenous ® administration. individually 5-ml vial of Paloxi injection contains 0.25 mg palonosetron bow as hydrochloride, 207.5 mg mannitol, edetate disodium dihydrate, trisodium citratedihydrate, citric aci d monohydrate, and water for injection for intravenous administration. The pH of the solution is 4.5 to 5.5.

clinical PHARMACOLOGY Mechanism of Action Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor and litt le or no affinity for other receptors. Cancer chemotherapy may be associated with a richly incidence of nausea and pass, particularly when received agents, such as cisplatin, are used. 5-HT3 receptors are located on the kernel terminals of the vagus in the periphery and centrally in the chemoreceptor propel zone of the field of operation postrema. It is thought that chemotherapeutic agents progress to nausea and vomiting by releasing serotonin from the enterochromaffin cells of the base bowel and that the released s erotonin then activates 5-HT3 receptors located on pneumogastric afferents to founding father the vomiting reflex. Pharmacodynamics The effect of palonosetron on business line pressure, heart rate, and electrocardiogram parameters including QTc...If you lack to get a beat essay, order it on our website: Ordercustompaper.com

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